Mannatech Science

To date, more than 2 patents have been issued for the technology related to Mannatech’s GI-PROBALANCE® formulation.

GI-ProBalance slimsticks
Probiotic and prebiotic supplement.* Gluten-free.

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GI-ProBalance Slimsticks: Technical Information

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Ingredients

OpenBifidobacterium breve

Bifidobacterium breve

Bifidobacterium breve is a species of lactic acid-producing bacteria that is naturally found in the human gastrointestinal (GI) tract. Bifidobacterium breve is used commercially as a probiotic—beneficial bacteria that help maintain the health of the intestinal tract, aid digestion and assist in nutrient absorption.* Probiotics can be found in some food sources, such as yogurt, and they can also be consumed as dietary supplements. Bifidobacterium breve seems to be well-tolerated when consumed by most people. No adverse effects from Bifidobacteria ingestion have been reported (1).

 This ingredient can be found in the following product:
   •  GI-ProBalance™ slimsticks
 

References

References

1. Natural Medicines: Comprehensive Database. Stockton, CA: Therapeutic Research Faculty, 2000.

Last updated March, 2011

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OpenBifidobacterium longum

Bifidobacterium longum

Bifidobacterium longum is a species of lactic acid-producing bacteria that is naturally found in the human gastrointestinal (GI) tract. A number of Bifidobacteria species are used as probiotics in the dietary supplement and food industries to help maintain GI tract health, aid digestion and assist in nutrient absorption.* Orally, Bifidobacterium longum seems to be well-tolerated by most people. No adverse effects from Bifidobacteria ingestion have been reported (1).

 This ingredient can be found in the following product:
   •  GI-ProBalance™ slimsticks
 

References

References

1. Natural Medicines: Comprehensive Database. Stockton, CA: Therapeutic Research Faculty, 2000.

Last updated March, 2011

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OpenFructo-oligosaccharides

Fructo-oligosaccharides

Fructo-oligosaccharides (FOS) typically refer to short-chain oligosaccharides comprised of fructose and glucose monosaccharide units. They exist naturally in plants and are commonly consumed in foods such as onions, bananas, lettuce and wheat. FOS are used in dietary supplements and functional foods as a type of prebiotic, a non-digestible carbohydrate that promotes the growth and/or activity of beneficial bacterial in the colon (1). The U.S. Food and Drug Administration (FDA) has been notified that industry considers FOS to be generally recognized as safe (GRAS) for its intended use and has not objected to its use for this purpose (GRN No. 000044).

This ingredient can be found in the following product:
   •  GI-ProBalance™ slimsticks
 

References

References

1. PDR for Nutritional Supplements. Montvale, NJ: Physicians' Desk Reference, Inc, 2008.

Last updated March, 2013

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OpenLactobacillus acidophilus

Lactobacillus acidophilus

Lactobacillus acidophilus is a strain of lactic acid-producing bacteria that is naturally found in the human gastrointestinal tract. It is commonly found in fermented milk products, such as yogurt, and can also be consumed as a dietary supplement. Lactobacillus acidophilus is considered a probiotic, beneficial bacteria that help maintain the health of the intestinal tract and aid in digestion. Probiotics also assist in nutrient absorption and help control the amount of harmful bacteria in the gut. Orally, Lactobacillus species are usually well-tolerated, the most common side effect being a mild case of flatulence that tends to subside as consumption continues (1).

This ingredient can be found in the following products:
   •  GI-ProBalance™ slimsticks
   •  MannaCLEANSE™ caplets
 

References

References

1.  Natural Medicines: Comprehensive Database. Stockton, CA: Therapeutic Research Faculty, 2000.

Last updated April, 2013

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OpenLactobacillus plantarum

Lactobacillus plantarum

Lactobacillus plantarum is a strain of lactic acid-producing bacteria that is naturally found in the human gastrointestinal tract. It is commonly found in fermented food products and can be consumed as a probiotic dietary supplement. Probiotics are beneficial bacteria that help maintain the health of the intestinal tract and aid in digestion. They also assist in nutrient absorption and help control the amount of harmful bacteria in the gut. Orally, Lactobacillus species are usually well-tolerated, the most common side effect being a mild case of flatulence that tends to subside as consumption continues (1).

This ingredient can be found in the following products:
   •  GI-ProBalance™ slimsticks
   •  MannaCLEANSE™ caplets
 

References

References

1. Natural Medicines: Comprehensive Database. Stockton, CA: Therapeutic Research Faculty, 2000.

Last updated March, 2011

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OpenLactobacillus rhamnosus

Lactobacillus rhamnosus

Lactobacillus rhamnosus is a species of lactic acid-producing bacteria that is naturally found in the human GI tract. It is commonly found in fermented food products, such as yogurt, and can be consumed as a probiotic dietary supplement. Probiotics are beneficial bacteria that help maintain the health of the intestinal tract, aid digestion and assist in nutrient absorption.* Orally, Lactobacillus species are usually well-tolerated, the most common side effect being a mild case of flatulence that tends to subside as consumption continues (1).

 This ingredient can be found in the following product:
   •  GI-ProBalance™ slimsticks
 

References

References

1. Natural Medicines: Comprehensive Database. Stockton, CA: Therapeutic Research Faculty, 2000.

Last updated March, 2011

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OpenStreptococcus thermophilus

Streptococcus thermophilus

Streptococcus thermophilus is a species of bacteria commonly used in the production of yogurt. For certain individuals who are normally unable to digest lactose, Streptococcus thermophilus, which produces lactic acid to break down the milk sugar lactose, can help improve digestion when present in dairy products. Streptococcus thermophilus is typically categorized as a species of probiotics in the dietary supplement and food industries (1). Probiotics are beneficial bacteria that help maintain the health of the intestinal tract.* The safety of consuming Streptococcus thermophilus is supported by the popularity of yogurt as a functional food around the world.

 This ingredient can be found in the following product:
   •  GI-ProBalance™ slimsticks
 

References

References

1. Guarner F, Perdigon G, Corthier G, Salminen S, Koletzko B, Morelli L. Should yoghurt cultures be considered probiotic? Br J Nutr 2005;93:783-6.

Last updated March, 2011

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Formulation Ingredients

OpenAscorbic acid

Ascorbic acid

Ascorbic acid, commonly known as vitamin C, is an essential water-soluble vitamin found mainly in fruits and vegetables, particularly in citrus fruits such as oranges. Vitamin C functions as a reducing agent and thereby demonstrates potent antioxidant activity. Vitamin C deficiency can lead to the disease scurvy, which involves the deterioration of elastic tissue, demonstrating the important role of ascorbic acid in the synthesis of connective tissues such as collagen in bones (1). Dietary vitamin C is efficiently absorbed through the intestine.
     Vitamin C is generally recognized as safe (GRAS) by the U.S. Food and Drug Administration (FDA) (21CFR182.8013). The U.S. FDA has established a Reference Daily Intake (RDI) of 60 mgs vitamin C for adults and children 4 or more years of age (21CFR101.9). RDIs are a set of dietary references for essential vitamins and minerals that are considered amounts sufficient to meet the daily requirements of healthy individuals. RDIs serve as the basis for calculating the percent daily value (%DV) amounts found on dietary supplement and food labels.

This ingredient can be found in the following products:
   •  GI-ProBalance™ slimsticks
   •  GlycoSlim® chocolate meal replacement
   •  GlycoSlim® vanilla meal replacement
 

References

References

1. Institute of Medicine. Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids. Washington, D.C.: National Academy Press, 2000.

Last updated March, 2013

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OpenGum acacia

Gum acacia

Gum acacia, also known as gum arabic, is the gum that exudes from the acacia tree, Acacia senegal or Acacia seyal. Gum acacia is a water-soluble dietary fiber used primarily to control the consistency of food and beverages. Monosaccharide constituents include galactose, arabinose, glucuronic acid and rhamnose (1). Gum acacia is included in the U.S. Food and Drug Administration (FDA) Inactive Ingredients Guide as safe to use in the amounts present in our products (2). It is also an approved food additive by the U.S. FDA (3).

This ingredient can be found in the following products:
   •  GI-ProBalance™ slimsticks
   •  PhytoMatrix® caplets
 

References

References

1. Whistler RL, BeMiller JN. Carbohydrate Chemistry for Food Scientists. St. Paul, Minn.: American Association of Cereal Chemists, Inc., 1999.

2. FDA Inactive Ingredients Guide.. http://www.accessdata.fda.gov/scripts/cder/iig/index.cfm . 2007.

3. Food and Drug Administration. EAFUS: A Food Additive Database. http://www.foodsafety.gov/~dms/eafus.html. 10-17-2008. 12-4-2008.

Last updated March, 2011

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OpenMaltodextrin

Maltodextrin

Maltodextrin is a polysaccharide produced from starch. Like starch, maltodextrin is easily digestible and absorbed through the intestine. As an excipient, maltodextrin is generally regarded as a nontoxic and nonirritant material (1). Maltodextrin is considered generally recognized as safe (GRAS) by the U.S. FDA for use as a direct food substance (21CFR184.1444).

This ingredient can be found in the following products:
   •  GI-ProBalance™ slimsticks
   •  GlycoSlim® chocolate meal replacement
   •  GlycoSlim® vanilla meal replacement
   •  Optimal Support Packets
   •  PhytoMatrix® caplets
 

References

References

1.  Handbook of Pharmaceutical Excipients. Washington, DC: Pharmaceutical Press and American Pharmacists Assn, 2006.

Last updated July, 2013

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OpenModified food starch

Modified food starch

Modified food starch refers to a type of food starch (i.e. corn, wheat, rice, potato or tapioca) that is modified by treatment with certain acids, enzymes or compounds that bleach or alter its chemical properties. It is used to thicken, to improve texture and to maintain the water content of foods. Modified food starch is approved for use as a food additive by the U.S. Food and Drug Administration (FDA) (21CFR172.892) (1).

This ingredient can be found in the following products:
   •  AmbroStart® drink mix
   •  EM•PACT® sports drink
   •  GI-ProBalance™ slimsticks
 

References

References

1. Food and Drug Administration. EAFUS: A Food Additive Database. http://www.foodsafety.gov/~dms/eafus.html. 10-17-2008. 12-4-2008.

Last updated November 2013

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OpenSilicon dioxide

Silicon dioxide

Silicon dioxide, also known as silica, is added to capsule and tablet formulations to reduce clumping (1). Silica is found in many foods, particularly whole grains (oats and barley), sugar beets, sugar cane, soybeans, turnips, green beans (2). The average intake of silica in adults is 14-21 mg/day (3). The bioavailability of silicate additives is low (4). Silica that occurs in food and water has not been shown to cause any adverse effects (3).

This ingredient can be found in the following products:
   •  AmbroStart® drink mix
   •  Ambrotose® Complex capsules
   •  BounceBack® capsules
   •  Catalyst™ caplets
   •  EM•PACT®
   •  GI-ProBalance™ slimsticks
   •  GlycoSlim® chocolate meal replacement
   •  GlycoSlim® vanilla meal replacement
   •  ImmunoSTART® tablets
   •  MannaCLEANSE™ caplets
   •  Optimal Support Packets
   •  PhytoMatrix® caplets
   •  PLUS™ caplets
   •  SPORT™ capsules
 

References

References

1. The Merck Index. Whitehouse Station, NJ: Merck & Co., 2006.

2. Nutritional Biochemistry and Metabolism. New York, New York: Elsevier, 1991.

3. Natural Medicines: Comprehensive Database. Stockton, CA: Therapeutic Research Faculty, 2000.

4. Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, D.C.: National Academy Press, 2002.

Last updated July, 2013

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OpenXylitol

Xylitol

Xylitol is a sugar alcohol that occurs naturally in many fruits and berries. It is often used as a sweetener substitute in foods, providing the same sweetness as refined sugars with less food energy (1). Xylitol is considered generally recognized as safe (GRAS) by the U.S. Food and Drug Administration (FDA) for use as a food additive (21CFR172.395) (2).

This ingredient can be found in the following products:
   •  GI-ProBalance™ slimsticks
   •  MannaBears™ supplement
   •  PLUS™ caplets
 

References

References

1. Handbook of Pharmaceutical Excipients. Washington, DC: Pharmaceutical Press and American Pharmacists Assn, 2006.

2. Food and Drug Administration. EAFUS: A Food Additive Database. http://www.foodsafety.gov/~dms/eafus.html. 10-17-2008. 12-4-2008.

Last updated June, 2012

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OpenYogurt flavor

Yogurt flavor

Yogurt flavor is made from fermented milk products. The characteristic tart flavor comes from the fermentation of lactose into lactic acid by the bacteria added in the process of making yogurt.

 This ingredient can be found in the following product:
   •  GI-ProBalance™ slimsticks
 

References

About Ingredients

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* This statement has not been evaluated by the Food and Drug Administration.
This product is not intended to diagnose, treat, cure or prevent any disease.